House File 128 - Enrolled House File 128 AN ACT RELATING TO CONTROLLED SUBSTANCES, INCLUDING AMENDING CERTAIN CONTROLLED SUBSTANCES SCHEDULES AND PRECURSOR SUBSTANCES REPORTING REQUIREMENTS, MAKING PENALTIES APPLICABLE, AND INCLUDING EFFECTIVE DATE PROVISIONS. BE IT ENACTED BY THE GENERAL ASSEMBLY OF THE STATE OF IOWA: Section 1. Section 124.204, subsection 4, Code 2023, is amended by adding the following new paragraphs: NEW PARAGRAPH . ca. Ethyl 2-(1-(5-fluoropentyl)-1H- indazole-3-carboxamido)-3,3-dimethylbutanoate. Other name: 5F-EDMB-PINACA. NEW PARAGRAPH . cb. Methyl 2-(1-(5-fluoropentyl)-1H-indole- 3-carboxamido)-3,3-dimethylbutanoate. Other names: 5F-MDMB-PICA; 5F-MDMB-2201. NEW PARAGRAPH . cc. N-(adamantan-1-yl)-1-(4-fluorobenzyl)- 1H-indazole-3-carboxamide. Other names: FUB-AKB48; FUB-APINACA; AKB48 N-(4-FLUOROBENZYL). NEW PARAGRAPH . cd. 1-(5-fluoropentyl)-N-(2-phenylpropan-2- yl)-1H-indazole-3-carboxamide. Other names: 5F-CUMYL-PINACA; SGT-25. NEW PARAGRAPH . ce. (1-(4-fluorobenzyl)-1H-indol-3- yl)(2,2,3,3-tetramethylcyclopropyl) methanone. Other name: FUB-144. NEW PARAGRAPH . cf. 2-(ethylamino)-1-phenylhexan-1-one). Other names: N-Ethylhexedrone; alpha-ethylaminohexanophenone.

House File 128, p. 2 NEW PARAGRAPH . cg. Alpha-Pyrrolidinohexanophenone. Other names: alpha-PHP; alpha-pyrrolidinohexanophenone; 1-phenyl-2- (pyrrolidin-1-yl)hexan-1-one. NEW PARAGRAPH . ch. 4-Methyl-alpha-ethylaminopentiophenone. Other names: 4-MEAP; 2-(ethylamino)-1-(4-methylphenyl) pentan-1-one. NEW PARAGRAPH . ci. 4’-Methyl-alpha- pyrrolidinohexiophenone. Other names: MPHP; 4’-methyl-alpha- pyrrolidinohexanophenone; 1-(4-methylphenyl)-2- (pyrrolidin-1-yl)hexan-1-one. NEW PARAGRAPH . cj. alpha-Pyrrolidinoheptaphenone. Other names: PV8; 1-phenyl-2-(pyrrolidin-1-yl)heptan-1-one. NEW PARAGRAPH . ck. 4’-Chloro-alpha- pyrrolidinovalerophenone. Other names: 4-chloro-alpha- PVP; 4’-chloro-alpha-pyrrolidinopentiophenone; 1-(4-chlorophenyl)-2-(pyrrolidin-1-yl)pentan-1-one. NEW PARAGRAPH . cl. 2-(ethylamino)-2-(3-methoxyphenyl) cyclohexan-1-one. Other names: methoxetamine; MXE. Sec. 2. Section 124.204, subsection 9, Code 2023, is amended by striking the subsection and inserting in lieu thereof the following: 9. Other substances. Any material, compound, mixture, or preparation which contains any quantity of the following substances or their optical, positional, and geometric isomers, salts, and salts of isomers: a. Fentanyl-related substances. “Fentanyl-related substance” means any substance not otherwise listed under this schedule or another schedule, and for which no exemption or approval is in effect under section 505 of the federal Food, Drug, and Cosmetic Act that is structurally related to fentanyl by one or more of the following modifications: (1) Replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle. (2) Substitution in or on the phenethyl group with alkyl, alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino, or nitro groups. (3) Substitution in or on the piperidine ring with alkyl, alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl,

House File 128, p. 3 amino, or nitro groups. (4) Replacement of the aniline ring with any aromatic monocycle whether or not further substituted in or on the aromatic monocycle. (5) Replacement of the N-propionyl group by another acyl group. b. 1-(1-(1-(4-bromophenyl)ethyl)piperidin-4-yl)-1,3- dihydro-2H-benzo[d]imidazole-2-one. Other names: brorphine, 1-[1-[1-(4-bromophenyl)ethyl]-4-piperidinyl]-1, 3-dihydro-2H-benzimidazol-2-one. c. 2-(2-(4-butoxybenzyl)-5-nitro-1H-benzimidazol-1- yl)-N,N-diethylethan-1-amine and its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers. Other name: Butonitazene. d. 2-(2-(4-ethoxybenzyl)-1H-benzimidazol-1- yl)-N,N-diethylethan-1-amine and its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers. Other names: Etodesnitazene; etazene. e. N,N-diethyl-2-(2-(4-fluorobenzyl)-5- nitro-1H-benzimidazol-1-yl)ethan-1-amine and its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers. Other name: Flunitazene. f. N,N-diethyl-2-(2-(4-methoxybenzyl)-1H- benzimidazol-1-yl)ethan-1-amine and its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers. Other name: Metodesnitazene. g. N,N-diethyl-2-(2-(4-methoxybenzyl)-5- nitro-1H-benzimidazol-1-yl)ethan-1-amine and its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers. Other name: Metonitazene. h. 2-(4-ethoxybenzyl)-5-nitro-1-(2- (pyrrolidin-1-yl)ethyl)-1H-benzimidazole and its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers. Other names: N-pyrrolidino etonitazene; etonitazepyne. i. N,N-diethyl-2-(5-nitro-2-(4-propoxybenzyl) -1H-benzimidazol-1-yl)ethan-1-amine and its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers. Other name: Protonitazene.

House File 128, p. 4 Sec. 3. Section 124.210, subsection 3, Code 2023, is amended by adding the following new paragraph: NEW PARAGRAPH . bg. Daridorexant. Sec. 4. Section 124.212, subsection 5, Code 2023, is amended by adding the following new paragraph: NEW PARAGRAPH . g. Ganaxolone (3alpha-hydroxy-3beta-methyl- 5alpha-pregnan-20-one). Sec. 5. Section 124B.2, subsection 1, Code 2023, is amended by adding the following new paragraph: NEW PARAGRAPH . ah. Methyl alpha-phenylacetoacetate and its optical isomers. Other names: MAPA; methyl 3-oxo-2- phenylbutanoate. Sec. 6. EFFECTIVE DATE. This Act, being deemed of immediate importance, takes effect upon enactment. ______________________________ PAT GRASSLEY Speaker of the House ______________________________ AMY SINCLAIR President of the Senate I hereby certify that this bill originated in the House and is known as House File 128, Ninetieth General Assembly. ______________________________ MEGHAN NELSON Chief Clerk of the House Approved _______________, 2023 ______________________________ KIM REYNOLDS Governor